IQGAP1 Back

IQ motif containing GTPase activating protein 1

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NCBI Description of IQGAP1
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.

Community Annotation of IQGAP1 Add / Edit IQGAP1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IQGAP1 is highly significantly mutated in
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IQGAP1 is significantly mutated in
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IQGAP1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for IQGAP1