INTS12 Back

integrator complex subunit 12

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NCBI Description of INTS12

INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008].

Community Annotation of INTS12 Add / Edit INTS12: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


INTS12 is highly significantly mutated in
INTS12 is significantly mutated in
Multiple myeloma
3 patients (1%)
combined cohort
26 patients (0%)
INTS12 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for INTS12