HIST1H1E Back

histone cluster 1, H1e

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NCBI Description of HIST1H1E
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HIST1H1E is highly significantly mutated in
HIST1H1E is significantly mutated in
Chronic lymphocytic leukemia
CLL
4 patients (2%)
HIST1H1E is near significance in

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HIST1H1E