GUSB Back

glucuronidase, beta

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NCBI Description of GUSB
This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. There are many pseudogenes of this locus in the human genome.

Community Annotation of GUSB Add / Edit GUSB: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GUSB is highly significantly mutated in
GUSB is significantly mutated in
Kidney clear cell
KIRC
4 patients (0%)
GUSB is near significance in

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GUSB