GNB1 Back

guanine nucleotide binding protein (G protein), beta polypeptide 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of GNB1
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals.

Community Annotation of GNB1 Add / Edit GNB1: Annotations

No community annotations yet for GNB1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GNB1 is highly significantly mutated in
GNB1 is significantly mutated in
GNB1 is near significance in
Chronic lymphocytic leukemia
CLL
2 patients (1%)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GNB1