GFAP Back

glial fibrillary acidic protein

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of GFAP
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Community Annotation of GFAP Add / Edit GFAP: Annotations

No community annotations yet for GFAP.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GFAP is highly significantly mutated in
GFAP is significantly mutated in
GFAP is near significance in
Endometrial
UCEC
9 patients (3%)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GFAP