FHIT Back

fragile histidine triad gene

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of FHIT
This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene.

Community Annotation of FHIT Add / Edit FHIT: Annotations

No community annotations yet for FHIT.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FHIT is highly significantly mutated in
(none)
FHIT is significantly mutated in
(none)
FHIT is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for FHIT