FGFBP1 Back

fibroblast growth factor binding protein 1

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NCBI Description of FGFBP1
This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4.

Community Annotation of FGFBP1 Add / Edit FGFBP1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FGFBP1 is highly significantly mutated in
FGFBP1 is significantly mutated in
combined cohort
PanCan
17 patients (0%)
FGFBP1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for FGFBP1