EZR Back


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NCBI Description of EZR

The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.

Community Annotation of EZR Add / Edit EZR: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


EZR is highly significantly mutated in
EZR is significantly mutated in
6 patients (6%)
EZR is near significance in
Multiple myeloma
3 patients (1%)
Glioblastoma multiforme
4 patients (1%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for EZR