EZH1 Back

enhancer of zeste homolog 1 (Drosophila)

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NCBI Description of EZH1

EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009].

Community Annotation of EZH1 Add / Edit EZH1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


EZH1 is highly significantly mutated in
EZH1 is significantly mutated in
combined cohort
34 patients (0%)
EZH1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for EZH1