EXOC4 Back

exocyst complex component 4

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of EXOC4
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Community Annotation of EXOC4 Add / Edit EXOC4: Annotations

No community annotations yet for EXOC4.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

EXOC4 is highly significantly mutated in
(none)
EXOC4 is significantly mutated in
(none)
EXOC4 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for EXOC4