EPS8 Back

epidermal growth factor receptor pathway substrate 8

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NCBI Description of EPS8

This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Community Annotation of EPS8 Add / Edit EPS8: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


EPS8 is highly significantly mutated in
EPS8 is significantly mutated in
EPS8 is near significance in
combined cohort
52 patients (1%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for EPS8