EIF2S2 Back

eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa

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NCBI Description of EIF2S2
Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

EIF2S2 is highly significantly mutated in
EIF2S2 is significantly mutated in
Endometrial
UCEC
9 patients (3%)
EIF2S2 is near significance in
combined cohort
PanCan
20 patients (0%)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for EIF2S2