EIF2S2 Back

eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of EIF2S2

Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation.

Community Annotation of EIF2S2 Add / Edit EIF2S2: Annotations

No community annotations yet for EIF2S2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


EIF2S2 is highly significantly mutated in
EIF2S2 is significantly mutated in
9 patients (3%)
EIF2S2 is near significance in
combined cohort
20 patients (0%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for EIF2S2