epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)

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NCBI Description of EGFR

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

Community Annotation of EGFR Add / Edit EGFR: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


EGFR is highly significantly mutated in
Glioblastoma multiforme
77 patients (26%)
Lung adenocarcinoma
44 patients (10%)
combined cohort
202 patients (4%)
EGFR is significantly mutated in
EGFR is near significance in
Lung squamous cell carcinoma
6 patients (3%)
Kidney clear cell
7 patients (1%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for EGFR