DSG4 Back

desmoglein 4

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NCBI Description of DSG4

This gene encodes a member of the desmoglein subgroup of desmosomal cadherins. The encoded protein is a transmembrane component in desmosomes and may play a role in cell-cell adhesion in epithelial cells. Mutations in the gene are associated with localized autosomal recessive hypotrichosis and potentially in other skin disorders. Alternate splicing results in multiple transcript variants.

Community Annotation of DSG4 Add / Edit DSG4: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


DSG4 is highly significantly mutated in
DSG4 is significantly mutated in
DSG4 is near significance in
combined cohort
86 patients (1%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for DSG4