DDX3X Back

DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked

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NCBI Description of DDX3X

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which interacts specifically with hepatitis C virus core protein resulting a change in intracellular location. This gene has a homolog located in the nonrecombining region of the Y chromosome. The protein sequence is 91% identical between this gene and the Y-linked homolog. Alternative splicing results in multiple transcript variants.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


DDX3X is highly significantly mutated in
7 patients (7%)
DDX3X is significantly mutated in
combined cohort
58 patients (1%)
DDX3X is near significance in
Chronic lymphocytic leukemia
2 patients (1%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for DDX3X