CHD8 Back

chromodomain helicase DNA binding protein 8

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NCBI Description of CHD8

This gene encodes a DNA helicase that functions as a transcription repressor by remodeling chromatin structure. It binds beta-catenin and negatively regulates Wnt signaling pathway, which plays a pivotal role in vertebrate early development and morphogenesis. Mice lacking this gene exhibit early embryonic death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Community Annotation of CHD8 Add / Edit CHD8: Annotations

No community annotations yet for CHD8.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CHD8 is highly significantly mutated in
CHD8 is significantly mutated in
Glioblastoma multiforme
9 patients (3%)
combined cohort
100 patients (2%)
CHD8 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CHD8