CHD4 Back

chromodomain helicase DNA binding protein 4

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NCBI Description of CHD4
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.

Community Annotation of CHD4 Add / Edit CHD4: Annotations

No community annotations yet for CHD4.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CHD4 is highly significantly mutated in
combined cohort
PanCan
132 patients (2%)
CHD4 is significantly mutated in
Endometrial
UCEC
36 patients (14%)
CHD4 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CHD4