CCAAT/enhancer binding protein (C/EBP), alpha

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NCBI Description of CEBPA

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Community Annotation of CEBPA Add / Edit CEBPA: Annotations

No community annotations yet for CEBPA.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CEBPA is highly significantly mutated in
CEBPA is significantly mutated in
Acute myeloid leukemia
13 patients (6%)
CEBPA is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CEBPA