BCL6 Back

B-cell CLL/lymphoma 6 (zinc finger protein 51)

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NCBI Description of BCL6
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

BCL6 is highly significantly mutated in
BCL6 is significantly mutated in
BCL6 is near significance in
Diffuse large B-cell lymphoma
DLBCL
5 patients (8%)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for BCL6