BAP1 Back

BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)

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NCBI Description of BAP1

The protein encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene.

Community Annotation of BAP1 Add / Edit BAP1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


BAP1 is highly significantly mutated in
Kidney clear cell
44 patients (10%)
combined cohort
82 patients (1%)
BAP1 is significantly mutated in
BAP1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for BAP1