ATP6V1C1 Back

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ATP6V1C1
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D.

Community Annotation of ATP6V1C1 Add / Edit ATP6V1C1: Annotations

No community annotations yet for ATP6V1C1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ATP6V1C1 is highly significantly mutated in
ATP6V1C1 is significantly mutated in
ATP6V1C1 is near significance in
combined cohort
PanCan
25 patients (0%)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ATP6V1C1