ASXL2 Back

additional sex combs like 2 (Drosophila)

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NCBI Description of ASXL2
ASXL2 is a human homolog of the Drosophila asx gene. Drosophila asx is an enhancer of trithorax (see MIM 159555) and polycomb (see MIM 610231) (ETP) gene that encodes a chromatin protein with dual functions in transcriptional activation and silencing (Katoh and Katoh, 2003 [PubMed 12888926]).[supplied by OMIM, Sep 2009].

Community Annotation of ASXL2 Add / Edit ASXL2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ASXL2 is highly significantly mutated in
ASXL2 is significantly mutated in
combined cohort
PanCan
75 patients (1%)
ASXL2 is near significance in
Bladder
BLCA
7 patients (7%)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ASXL2