glucocorticoid receptor DNA binding factor 1

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NCBI Description of ARHGAP35

ARHGAP35, also known as GRLF1, the human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ARHGAP35 is highly significantly mutated in
36 patients (14%)
combined cohort
112 patients (2%)
ARHGAP35 is significantly mutated in
ARHGAP35 is near significance in
Lung squamous cell carcinoma
10 patients (5%)
Lung adenocarcinoma
14 patients (3%)
Head and neck
13 patients (3%)
Kidney clear cell
5 patients (1%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ARHGAP35